Irisu Syndrome!

Irisu Syndrome! is a falling blocks puzzle game. As colored blocks fall down from the top of the screen, the layer must use their mouse to launch same-colored blocks at each other to clear them from the board and score points. The player's health gradually and automatically decreases as the game continues, and the only way to restore it is to clear blocks before they hit the bottom of the board.

As the game progresses, it tells the story of four young adults who have known each other since elementary school, including the bunny-loving protagonist Kyouko Irisu. It soon becomes clear that all is not right in this group of friends, and the player's performance with the puzzles will affect how the plot is resolved.